New study uses Salipro technology to reveal cryoEM structure of important cancer target

Most cancers depend on the export of lactate from the cells by so-called monocarboxylate transporters (MCTs). Salipro® technology helped to reveal how MCT1 forms a heterodimeric complex with its chaperone embigin and the implications on substrate affinity. 

Publication Reference:

B. Xu et al., Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Reports 40, 111343 (2022)