New research - Salipro & cell death

Acid-induced cell death occurs in stroke, cancer or heart attack. Using Salipro® technology, the Jentsch and Long labs solved several structures of the chloride channel ASOR (aka TMEM206), an attractive single target for the acid-sensitive cell entry of ions across membranes. Congrats!

Publication Reference:
C. Wang, M. M. Polovitskaya, B. D. Delgado, T. J. Jentsch, S. B. Long, Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Sci. Adv. 8, 1–13 (2022).